Detection of Phylogenetic Groups and Drug Resistance Genes of Escherichia coli Causing Urinary Tract Infection in Southwest Iran

Background: Many bacteria can cause urinary tract infections (UTIs), among which Escherichia coli is the most common causative agent. strains are divided into eight phylogenetic groups based on new Quadroplex-PCR method, different in terms of patterns resistance to antibiotics, virulence, and environmental characteristics. Objectives: This study aimed determine prevalence drug genes E. causing UTIs. Methods: In this descriptive cross-sectional study, 129 isolates obtained from culture patients with UTIs were evaluated for using method Clermont et al. The identification antibiotic was performed multiplex polymerase chain reaction (PCR) method. Results: concerning distribution isolates, group B2 (36.4%) group, followed by phylogroups C (13.2%), clade I (10.1%), D (9.3%), A (3.1%) while B1 F not observed any 20.2% had an unknown state. Also, out total frequency tetA, tetB, sul1, sul2, CITM, DfrA, qnr 59.7%, 66.7, 69, 62, 30.2, 23.3, 20.2%, respectively. there a significant relationship between antibiotics (P = 0.026), cefotaxime 0.003), nalidixic acid 0.044) groups. No genes. Conclusions: results showed that belonging highest other phylogroups, also, drug-resistant higher phylogroup. These show phylogroup has more effective role compared be considered genetic reservoir resistance.